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S.B. Ankara Ulucanlar Göz Eğitim ve Araştırma Hastanesi, Ankara, Uzm. Dr. A 45-year-old woman came to retina clinic with loss of vision in the right eye. Ischemic central retinal vein occlusion (CRVO) was diagnosed. The laboratory tests for the etiology revealed Factor V Leiden mutation (FVL, R506Q mutation). B-scan ultrasonography revealed vitreopapillary traction associated with disc edema and peripapillary retinal detachment. She underwent vitrectomy, posterior hyaloid stripping and peripapillary subretinal tissue-plasminogen activator (t-PA) injection to relieve the traction, facilitate blood removal and increase the retinal perfusion. Optic nerve head elevation and retinal detachment resolved within the first postoperative week. Retinal hemorrhages cleared within the first 2 weeks and her vision improved from light perception to 20/400. Optic disc traction may complicate the course of ischemic CRVO and may benefit from vitrectomy combined with focal delivery of thrombolytic agents. Keywords : Optic disc traction syndrome, central retinal vein occlusion, factor V mutation, tissue-plasminogen activator