2M.D., Ulucanlar Eye Training and Research Hospital, Ankara/TURKEY
3M.D. Asistant, Ulucanlar Eye Training and Research Hospital,
4M.D. Professor, Ulucanlar Eye Training and Research Hospital, Ankara/TURKEY Purpose: To assess aqueous humour total antioxidant capacity (TAC) concentrations in proliferative diabetic retinopathy (PDR) patients treated with panretinal laser photocoagulation (PLP) and untreated with panretinal laser photocoagulation in comparison to non-diabetic cases.
Materials and Methods: Aqueous humour samples were collected from patients who had cataract surgery, treated with PLP diagnosed as PDR (n: 16), (Group 1), untreated with PLP diagnosed as PDR (n: 10), (Group 2), and with no diabetes (n: 20), (Group 3). Aqueous humour was obtained at cataract surgery, and the levels of TAC were measured by the Erel Method.
Results: Mean aqueous humour level of TAC was 0.72±0.31 (0.25-1.45) mmol Trolox equivalent/L in Group 1 eyes, 1.1±0.95 (0.5-3.8) mmol Trolox equivalent/L in Group 2 eyes, and 35.3±24.8 (9-101) mmol Trolox equivalent/L in the eyes of the control group with no diabetes (Group 3). Aqueous humour TAC concentrations were significantly lower in the patients with Group 1 and Group 2 in comparison to Group 3 (p=0.001). A significant alteration was not observed between Group 1 and Group 2 patients (p=0.09).
Conclusions: Aqueous humour TAC concentrations are decreased in PDR patients treated and untreated with PLP. There is no affirmative effect of PLP on to the TAC concentrations.
Keywords : Aqueous humour, panretinal laser photocoagulation, proliferative diabetic retinopathy, total antioxidant capacity