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Marmara Üniversitesi Tıp Fakültesi Göz Hastalıkları A.B.D. Purpose: Proliferative vitreoretinopathy (PVR) is the leading cause of failure in rhegmatogenous retinal detachment surgery. Several lines of evidence support the role of inflammatory and immunologic phenomenon in the pathogenesis of PVR. In this study we investigated tha presence of two cell adhesion molecules, soluble VCAM-1 and solubleL-selectin, in subretinal fluids (SRF) of patients suffering from rhegmatogenous retinal detachment and their relationship between the severity of PVR, the duration of retinal detachment and the extent of detachment.
Method: Subretinal fluids were collected from 27 patients with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy or uncomplicated retinal detachment. Levels of sVCAM-1 and sL-selectin were quantified with ELISA.
Results: The levels of sVCAM-1 and sL-selectin were found to be higher in patients with Grade C PVR and in the detachments lasting longer than 8 weeks of duration. While no significant difference was detected between groups when sVCAM-1 concentrations were compared according to the duration of detachment, the levels of sL-selectin were significantly higher in the detachments extending to 4 quadrants of the retina than those extending to 2 quadrants.
Conclusion: The present study supports growing evidence that these cell adhesion molecules are involved in the inflammatory process during the development and progression of PVR. Further understanding of the mechanisms that initiate and control the inflammatory response may have important pathogenetic and therapeutic implications in PVR. Keywords : Subretinal fluid, rhegmatogenous retinal detachment, proliferative vitreoretinopathy, vascular cell adhesion molecule-I (VCAM-1), L-selectin