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SSK Okmeydanı Eğt.Hastanesi Göz Hastalıkları Uzmanı To evaluate the incidance of cystoid macular edema (CME) in Behcefs disease and assign the appropiate treatment methods for CME, the charts of 165 patients with posterior uveitis associated with Behcet's disease were reviewed retrospectively. The fundus examination were possible in 289 eyes. One-hundred and seventy-seven eyes of 106 patients were diagnosed with CME by fundus examination and fundus flouressein angiography (FFA). The prognosis of CME and response to the treatments was evaluated in 88 patients who were regularly followed-up more than 12 months. The incidance of CME was found to be 66% in patients with posterior uveitis associated Behcet's disease. CME was found in 143 eyes of 88 patients who were included into the study. Eighty-three eyes (28.8%) of 51 patients had regression of CME. Fifty-one eyes of 37 patients had developed cystoid macular degeneration and 9 eyes had macular hole. The eyes that had cystoid macular degenerations or macular hole had more frequent activations of uveitis than the eyes that had regretions of CME (p<0.0001). Eight of 9 eyes (88.9%) with macular hole also had partici posterior vitreus detachment (PVD). Thirty-three eyes (64.7%) with macular degeneration had partici PVD, 8 (15.7%) eyes had total PVD and 10 (19.6%) eyes had no PVD. These findings indicate that an immediate control of the activations of the uveitis is necessary in order to decrease CME and prevent permanent demage. An appropiate immunosupressive treatment should be begin as soon as possible. This study shows us complementary medical treatment can not prevent development of macular degeneration or macular hole formation if the activations are not be controlled. Keywords : Behçet's disease, cystoid macular edema, macular hole, macular degeneration, posterior vitreus detachment