Materials and Methods: OCTA imaging of 36 eyes of 36 patients (24 type 1 CNV, 12 type 2 CNV) with AMD under follow-up in our clinic were reviewed retrospectively. Neovascular complex were qualitatively and quantitatively analyzed at baseline and at follow-up visits.

Results: Mean follow-up time was 19.81±6.21 (12-31) months, and median number of injections was 6 (1-11). No signifi cant difference was found for feeder vessel, branching numerous tiny capillaries, loops, peripheral arcade, loop and anostomoses between the groups. However, perilesional hypointense halo was seen more frequently in type 2 CNV group at baseline and final follow-up (p=0,002, p=0,021, respectively). GLD of CNV, selected CNV area and flow area measurements were found to be higher in type 1 CNV at baseline and follow-up (p=0.004, p=0.001, p=0.002, respectively) (p<0,001, p<0,001, p<0,001, respectively). There was no statistically signifi cant changes in GLD of CNV, CNV area and flow area both type 1 CNV and type 2 CNV after treatment.

Conclusion: OCTA provides noninvasive imaging in differential diagnosis and follow-up of CNV subtypes secondary to AMD. Type 2 CNV was characterized by smaller CNV area, flow area and GLD of CNV compared with type 1 CNV. The GLD of CNV, selected CNV area and flow area in both groups showed no signifi cant change from baseline after PRN treatment at least more than 1 year of follow-up. Keywords : Age-related macular degeneration, Choroidal neovascularization, Type 1 choroidal neovascularization, Type 2 neovascularization, Optical coherence tomography angiography