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University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ophthalmology Department, Ankara, Turkey DOI : 10.37845/ret.vit.2022.31.29 Retinitis pigmentosa sine pigmento (RPSP) is an atypical form of retinitis pigmentosa without hyper-pigmented lesions in the fundus. Diagnosis is difficult due to the absence of typical fundus findings. In this report, we present a case of RPSP associated with optic disc drusen and cystoid macular edema in which best corrected visual acuity was 0.5 in the right eye and 0.7 in the left. The aim of this report is to demonstrate a case of RPSP who presented with unexplained vision loss in both eyes and was diagnosed with multimodal imaging methods. Keywords : Electroretinography, Carbonic anhydrase inhibitor, Cystoid macular edema, Optic disc drusen, Retinitis pigmentosa sine pigmento