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Gazi Yasargil Training and Research Hospital., Ophthalmology, Diyarbakir, Türkiye DOI : 10.37845/ret.vit.2025.34.21 Idiopathic retinal vasculitis, aneurysm, neuroretinitis (IRVAN) syndrome is an idiopathic disease that usually affects young women. Macular edema and neovascular complications secondary to retinal ischemia are the main causes that threaten vision. There is no accepted standard algorithm in the treatment of IRVAN syndrome. Laser photocoagulation is used for retinal ischemia, and intravitreal antivascular endothelial growth factor or dexamethasone implant injection is applied in the presence of macular edema. In systemic treatment, steroids, conventional immunosuppressive or biological agents are used. Fundus fluorescein angiography and optical coherence tomography are used in the diagnosis and follow-up of patients. In this case report, the clinical and angiographic findings of two female patients who were diagnosed with IRVAN and received local and systemic treatment are described. Keywords : retinal vasculitis, aneurysm, neuroretinitis, IRVAN syndrome