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Düzce Üniversitesi Tıp Fakültesi Göz Hastalıkları A.D., Düzce, Prof. Dr. Proliferative diabetic retinopathy (PDR) is the leading cause of severe vision loss in diabetic patients. Laser treatment was the major method of treatment without any alternative until the early 2000’s. However, currently intravitreal injection of vascular endothelial growth factor antagonists provide new horizons in medical treatment of PDR. We evaluated the current medical treatment methods of PDR in this review. Keywords : Proliferative diabetic retinopathy, laser photocoagulation, vascular endothelial growth factor (VEGF)