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¹İnönü Üniversitesi Turgut Özal Tıp Merkezi, Göz Hastalıkları A.D., Malatya, Prof. Dr.
²İnönü Üniversitesi Turgut Özal Tıp Merkezi, Göz Hastalıkları A.D., Malatya, Asist. Dr.
³Malatya Devlet Hastanesi, Göz Hastalıkları Kliniği, Malatya, Uzm. Dr.
⁴Kahta Devlet Hastanesi, Göz Hastalıkları Kliniği, Adıyaman, Uzm. Dr. Purpose: To investigate the effect on surgical success of intravitreal bevacizumab given before pars plana vitrectomy in diabetic patients.
Materials and Methods: All patients were divided into two groups: those given bevacizumab before surgery (Group 1; 32 patients) and those not given bevacizumab (Group 2; 50 patients). The groups were compared with regard to the frequencies of retinal tear and active bleeding during surgery, postoperative changes in best corrected visual acuity (BCVA) and intraocular pressure (IOP), postoperative frequencies of retinal detachment and recurrent vitreous hemorrhage (VH), and development of rubeosis.
Results: During the surgery, retinal tear was observed in 2 patients (6.3%) from Group 1 and in 4 patients (8%) from Group 2; active bleeding was seen in 2 patients (6.3%) from Group 1 and in 4 patients (8%) from Group 2. After the surgery, retinal detachment was found in 1 patient (3.1%) from Group 1 and in 2 patients (4%) from Group 2; recurrent VH was found in 4 patients (12.5%) from Group 1 and in 14 patients (28%) from Group 2. In the postoperative controls, an increase in IOP was determined in 6 patients (18.8%) from Group 1 and in 9 patients (18%) from Group 2. In the postoperative controls, an increase in the mean BCVA value was determined in 24 patients (75%) from Group 1 and in 32 patients (64%) from Group 2.
Conclusion: In the patients with PDR, anti-VEGF (vascular endothelial growth factor) drugs positively influence the surgical success by causing the active new vasculature to be regressed and consequently allowing easy cleaning of the membranes during surgery. Due to the anti-inflammatory and anti-edematous effect of anti-VEGF drugs, better BCVA is obtained after surgery. Keywords : Bevacizumab, proliferative diabetic retinopathy, pars plana vitrectomy