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Hacettepe Üniversitesi Tıp Fakültesi Göz Hastalıkları Anabilim Dalı Ankara, Prof. Dr. Changes in the vitreous during aging play role in a variety of vitreoretinal disorders. Aging causes rheologic, biochemical and structural changes in the vitreous. In this paper, changes in the vitreus during aging will be reviewed and the hypotheses for the mechanism of posterior vitreous detachment will be summarized. Keywords : Vitreous, aging, posterior vitreous detachment, synchisis