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Doç. Dr., Serbest Hekim İmpairment of inner and outer blood-retina barriers in diabetes results in macular edema and subsequent visual loss. Regulation of systemic risk factors is important in the treatment of diabetic macular edema (DME). In addition, macular laser photocoagulation, intravitreal corticostreoids and frequently intravitreal anti vascular endothelial growth factors are often performed for the treatment of DME. Some patients have vitreomacular interface abnormalities such as vitreomacular traction or epiretinal membrane. In eyes with DME and vitreomacular traction or epiretinal membran, successful results can be achieved with pars plana virectomy (PPV) ± internal limiting membrane (ILM) removal. However, PPV ± ILM removal is contraversial in eyes with DME and without vitreomacular interface abnormalities. Prospective randomized comparative studies are needed for a reliable conclusion. Keywords : Diabetic macular edema