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Prof. Dr., İnönü Üniversitesi, Göz Hastalıkarı Anabilim Dalı, Malatya, Türkiye The viteoretinal interface has been identifi ed as the site of many different forms of retinal pathology. The posterior vitreous cortex consists of densely packed collagen fibrils that insert superficially into the internal limiting membrane (ILM) of the retina and attach to the ILM by glue-like macromolecules, such as laminin, fibronectin, chondroitin, and heparan sulphate proteoglycans. The strongest vitreoretinal adhesions have been described at the optic disc, over the retinal blood vessels and at the macular area. Before the development of optical coherence tomography (OCT), clinicians relied on astute clinical observation and fundoscopy, fl uorescein angiography (FA), and postmortem histology to make assumptions about the role the vitreoretinal interface plays in macular pathology. OCT has given us the ability to view the macula in cross sections and thus has improved our understandings of the following known clinical entities; posterior vitreous detachment (PVD), vitreomacular traction (VMT) syndromes, macular holes (MH), and epiretinal membranes (ERMs). This article discusses the diagnosis and management of abnormal vitreoretinal interface disorders. Keywords : Vitreoretinal interface, diagnosis, management, OCT