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¹SSK Şevket Yılmaz Hastanesi , Biyokimya ve Klinik Biyokimya,
²SSK Şevket Yılmaz Hastanesi, Göz Hastalıkları Kliniği,
³SSK Şevket Yılmaz Hastanesi, Aile Hekimliği Kliniği,
⁴Marmara Üniversitesi Tıp Fakültesi, Endokrinoloji Anabilim Dalı,
⁵Yeditepe Üniversitesi Tıp Fakültesi, Halk Sağlığı Anabilim Dalı Purpose: Increased serum concentration of sialic acid is a marker of the acute-phase response. Elevated concentrations of sialic acids in type II diabetic patients have been shown in previous studies. The aim of this study is to determine the relation between sialic acid elevation and diabetic retinopathy.
Methods: Type II diabetic 49 patients (F/M - 30/19, mean age 56 ± 7 years old) were included in this study. The patients were divided into three groups; patients without retinopathy (Group R0, n: 19), patients with nonproliferative retinopathy (Group R1, n: 15) and patients with proliferative retinopathy (Group R2, n: 15). Healthy 38 volunteers were included as control group (F/M, 19/19, 55 ± 6 years old). Results: A significant difference (P<0.05) was observed in serum sialic acid values in diabetic patients (R0=2.00 ± 0.47, R1=2.17± 0.30, R2= 2.25 ± 0.5 mmol/L) compared with healthy controls (C=1.81± 0.30 mmol/L). Serum sialic acid level was higher in the nonproliferative retinopathy group but the difference between groups was not statistically insignificant (P>0.05).
Conclusions: There is no correlation between grading of retinopathy and serum sialic acid level. Keywords : Sialic acid, type II diabetes, retinopathy