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Serbest Hekim, Ankara, Doç Dr. Perfluorocarbon liquids (PFCL) are fluorinated synthetic analogues of hydrocarbons containing carbon-fluorine bonds. PFCL’s are colorless, odorless and possess high density (1.6 to 2.1 specific gravitiy) and low viscosity (2 to 3 centistokes at 25oC). These liquids are all optically clear and have a refractive indexes slightly different from saline, allowing the use of conventional contact lenses without optic aberrations. The difference in refractive index also creates a visible interface between saline and PFCL. They have low surface tension this property decreases the likehood of subretinal migration of PFCL. The boiling point of PFCL is higher than water, allowing the application of endophotocoagulation. The most commonly used PFCLs are perfluoro-n-octane, perfluorodecaline and perfluoroperhydrophenanthrene. PFCLs compared of only carbon and fluorine atoms have greater biologic stability than those compounds containing nitrogen, oxygen and hydrogen. Their high specific gravity allow for stabilizing the retina during peeling and delamination of membranes as a third hand. Their significant tamponate force is approximately six times greater than that of fluorosilicone oil. PFCLs are safe for intraoperative use, they cannot be left in the vitreous cavity for extended periods because of ocular toxicity. Keywords : Perfluorocarbon liquids