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¹M.D. Associate Professor, OSM Ortadoğu Hospital, Eye Clinic, Şanlıurfa/TURKEY
²M.D. Associate Professor, Gaziosmanpaşa University Faculty of Medicine, Department of Ophthalmology, Tokat/TURKEY Purpose: To investigate comparatively plasma and vitreous homosistein (Hcy) levels between the patients with proliferative diabetic retinopathy and the patients with nonproliferative ocular disease.
Material and Methods: Plasma and vitreous samples were obtained simultaneously at the time of vitreoretinal surgery from 16 type 2 diabetic patients with proliferative retinopathy and 13 nondiabetic patients with nonproliferative ocular diseases. Hcy levels were determined by high-performance liquid chromatography.
Results: The vitreous and plasma Hcy concentrations for the diabetic group were (median;range) 1.4 mol/L (0.25-4.3) and 19.55 mol/L (1.8-39.8), respectively. The vitreous and plasma Hcy concentrations for the control group were (median; range) 1.8 mol/L (0.1-3) and 4 mol/L (2-17.2), respectively. Plasma Hcy concentrations for the diabetic group were significantly higher than those for the control group (p=0.004). A remarkable positive correlation between vitreous and plasma Hcy concentrations was present only for the diabetic group (Spearman's, rho=0.487; p=0.056).
Conclusion: Plasma Hcy levels in the patients with PDR were higher than control group. There was no difference of Hcy levels between diabetic and control groups probably due to no severe breakdown of the blood-retina barrier. Keywords : Diabetic retinopathy, homosistein, plasma, vitreous